WHAT CAUSES DIABETES: A VIRAL CAUSE?

April 11th, 2011
In 1864, a Norwegian scientist reported that a patient developed diabetes after getting the mumps. Since then, more evidence has been found to link Type I diabetes with infectious diseases. Medical workers have noticed that diabetes in children, normally a rather rare disease (though it is growing ever more common), tends to occur in clusters. A number of cases will suddenly crop up in a particular area, and these outbreaks sometimes follow an epidemic of a viral disease, such as mumps or rubella (German measles). Coxsackie viruses (common viruses that can cause colds and intestinal infection) have also been implicated.
New cases of Type I diabetes seem to occur seasonally: most in the autumn and winter and least in the summer and spring—just like the incidence of many viral diseases. In some cases, diabetes “epidemics” follow virus epidemics closely; in others, there is a period of about three or four years between the outbreak of the viral disease and the appearance of diabetes symptoms.
Of course, it might be that the extra stress of the viral disease is just too much for a person who happens to have a weak pancreas, and the gland breaks down when the body is besieged by the disease germs. But researchers began to wonder whether the viral illness might actually damage the pancreas. Viruses might invade the pancreas and destroy the beta cells. Or there might be a more indirect effect, involving a mistaken attack by the body’s own defenses. The virus particles might happen to be chemically similar to part of the surface of the beta cells. (This kind of accidental similarity of environmental proteins to body biochemicals is called molecular mimicry.) Then antibodies produced by the body to attack the viruses would also attack and destroy beta cells. In any case, as beta cells are destroyed, the amount of insulin produced is greatly reduced. When 80 to 90 percent of the beta cells have been destroyed, the symptoms of diabetes develop quite suddenly.
There is a good deal of evidence to support the molecular mimicry theory. People with insulin-dependent diabetes usually make little or no insulin, and examinations of tissue from their pancreases show that beta cells have indeed been destroyed. Antibodies against these cells can be found circulating in the blood of a person with Type I diabetes. In fact, antibodies against one beta cell substance (glutamic acid decarboxylase, or GAD) may appear years before diabetes develops. Now researchers have confirmed that GAD is remarkably similar to a protein of the Coxsackie viruses.
All children catch viral diseases, usually quite a number of them during the growing years. Yet most children don’t develop diabetes. What determines that a virus infection will cause diabetes in one child, while another child will suffer the same infection and recover with full health?
If insulin-dependent diabetes is indeed an autoimmune disease—one in which the body makes antibodies against a virus that will also attack its own body cells—then a child who does not develop diabetes after a virus infection may just have been lucky enough not to produce those destructive antibodies. Each person produces his or her own unique antibodies against any particular germ or chemical. So some children may produce antibodies that simply cure them of the viral infection without affecting the pancreas.
Another possibility is that a person may inherit a pancreas or an immune system that is particularly susceptible to molecular mimicry. Researchers have found that most people with Type I diabetes have specific types of chemicals on the surfaces of their beta cells that are not usually found in other people. These cell-surface chemicals, which are hereditary, might be the chemicals against which a person’s body makes antibodies when viruses attack. (In Type II diabetes, this sort of correlation with special cell-surface chemicals is not seen.)
Although viruses may be implicated in Type I diabetes, this does not mean that diabetes is a contagious disease, like colds or mumps or TB. There is no “diabetes virus,” and you can’t catch diabetes by talking to, touching, or even kissing someone who has diabetes.
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FIGHTING BREAST CANCER

April 6th, 2011
Just a few years ago, cancer experts were enthusiastic about the strong possibility of soon canceling out breast cancer in women. The doctors had learned to use surgery and radiation treatment more precisely to attack the wildly growing cells. They also discovered how to shower the malignancy with strong anticancer drugs. They had new medications to protect healthy tissue from the bad effects of the drugs. Scientists also expected to rout out the cause of the disease, and with that knowledge they had hoped to cure breast cancer or to prevent it, or both.
But it has not happened – yet.
The American Cancer Society reports that, with 183,000 new cases annually, breast cancer kills 46,000 women each year. A woman, who lives to age 85, runs a one-in-nine chance of contracting breast cancer in her lifetime. Despite new therapies, the death rate has hardly changed in 50 years, and 70 percent of new cases are diagnosed in women who have no known risk factors for the disease.
That is dark news. Dr. Samuel Broder, director of the National Cancer Institute (NCI) in Bethesda, Maryland, maintains, “No question that we have a basis for optimism, but we should have no illusions about how difficult and formidable a problem breast cancer is. There won’t be a breakthrough tomorrow morning.”
Nobody knows that better than Dabney Allen, 49, a homemaker in MacLean, Virginia. Doctors first found a lump in a mammogram (a breast X-ray) of her right breast in 1990. “The biopsy showed that I had the kind of cancer that was 40 percent likely to recur,” Mrs. Allen tells Parade, “so I had both breasts removed.” After surgery, the doctors treated her with four potent drugs. “But the cancer recurred in March, under my right arm and along the scar,” Mrs. Allen says. “It spread to bone and to a spot on the chest wall. So my doctors say, ‘Let’s treat this as a chronic disease and not a terminal one.’”
Mrs. Allen will take drugs to kill her cancer cells. It is no cure, but she hopes by this method to alleviate the pain and stay comfortable for as long as possible.
The incidence of breast cancer increased by more than 30 percent from 1980 to 1987, prompting some to call the disease an epidemic. However, the American Cancer Society and the NCI believe the increase was due to more women having mammograms, which caught their cancer early. And Dr. Vincent DeVita, Jr., former head of the NCI, notes, “There is a definite decline in the death rate among young women with breast cancer.”
Still, Dr. Daniel Kopans, an associate professor of radiology at Harvard Medical School, believes that the number of new cases is increasing. Is there an epidemic? “Absolutely,” says Dr. Susan Love, director of University of California at Los Angeles’s Breast Center. “There are too many women dying of breast cancer, and we have to do something about it.”
What about mammograms? Dr. Kopans is angry with the NCI for its recent conclusion that women aged 40 to 49 do not benefit from annual mammograms. “If you screened all the women in the U.S. aged 40 to 49, you would save 3,000 lives a year,” Kopans estimates. The American Cancer Society and American Medical Association maintain that there is sufficient evidence to continue screening women in that age group.
However, several studies have shown that mammography screening provides little or no benefit for women under 50. Studies in the Netherlands, the United Kingdom, and Sweden, plus a Canadian study of 90,000 women, all showed that death rates from breast cancer for women in their 40s were the same whether or not they had screening mammograms.
“Mammography screening works great over 50,” says Dr. Love. “It has never really been proved to work that well in women under 50. The answer is: We need to find something that works better, not pay for something that doesn’t work as well.”
*10/266/5*

BOTOX ALL AROUND: EXCESSIVE SWEATING AND CHEST EXCESSIVE SWEATING

March 26th, 2011

It doesn’t classify as a cosmetic problem in the traditional sense, but profuse sweating (hyperhidrosis) is a big issue for a lot of people. Picture a supermodel walking down a runway with an armpit stain or a businessman sealing a deal with a clammy handshake and it becomes clear why many people are desperate for a solution. It so happens that the neurotransmitter (acetylcholine) that Botox affects in the face is the same one that triggers the sweat glands under the arms, in the palms of the hands, the soles of the feet and the forehead. Treating these areas with Botox temporarily reduces or even halts sweat production, with results lasting anywhere from six to eight months.
CHEST
Isn’t it odd to see a perfectly unlined face against a chest full of lines?  I think so and so do the patients whom I’ve treated in that area. I remember one patient in particular gushing about the thrill of waking up in the morning and not having a network of tines running in all directions across their chest.
*53\82\8*

COMMON SKIN DISEASES: WARTS

March 19th, 2011

There is no proof that warts are caused by a virus, but the vast majority of medical opinion now inclines to the view that a specific virus is responsible. Warts occur most frequently on the hands, the face, the soles of the feet, and the neck. Ordinary warts, called verrucae vulgaris are hard grayish-yellowish or brownish elevations on the skin of varying size. Juvenile warts are usually smaller. Unless the wart is in intimate contact with a nerve ending it is not likely to be painful. Warts may grow rapidly and spread, or they may remain isolated and stop growing or disappear, often without any special treatment.
Warts may be destroyed with acid, or with carbon dioxide snow or with the X-ray. For ordinary juvenile warts a paste containing salicylic acid is sometimes effective. If warts are large or disfiguring, the best treatment may be simply removing them surgically.
A new method of treatment is simply action of cold water for a half hour.
*8/318/5*

SUNBURN: AVOIDING RED – USE SUNSCREEN

March 12th, 2011

Before gardening, bike riding or starting any kind of prolonged outdoor activity, get in the habit of putting on sunscreen, especially during peak sunburn hours. Sunscreens contain chemicals that absorb UV light before it can damage skin. The products are rated on the sun protection factor (SPF) scale. Dermatologists consider an SPF 15 to be the minimum acceptable protection. This will allow the average man to stay in the sun 15 times longer than normal without burning.
Coat exposed areas liberally and thoroughly; avoid those telltale and painful red splotches on missed spots. Be aware that sweating, wiping off with a towel or prolonged immersion in water can erode your protection. Reapply the sunscreen at regular intervals. And be sure to slap some on your kisser—men are a lot more susceptible to lip cancer than their lipstick-wearing female counterparts.
Also, buy a sunscreen that filters out two types of ultraviolet light, UVA and UVB. UVB is the main culprit in sunburn, but UVA, which penetrates more deeply into the skin, is thought to be involved in other kinds of skin damage. Ironically, doctors say, exposure to UVA is on the rise. The reason? People stay in the sun longer with sunscreens that block only UVB or contain less UVA block. And, they say, the use of UVA tanning machines is increasing.
*631\257\8*

CAUSES OF PREMATURE EJACULATION: EXCESSIVE SENSITIVITY TO EROTIC SENSATIONS AND STRESSFUL SITUATIONS

February 26th, 2011

EXCESSIVE SENSITIVITY TO EROTIC SENSATIONS: It stands to reason that excessive stimulation can result in early ejaculation. If, therefore, ways and means can be found to reduce this excessive sexual stimulation during foreplay or intercourse, the disability could be cured. Various therapies have been tried, such as applying an anaesthetic ointment on the glans penis (Procaine), Kegal exercises involving contracting and relaxing the pubococ-cygens, mental diversion by thinking of something non-sexual and drugs like Melleril which produce a ‘dry ejaculation’ by paralysing the internal sphincter of the bladder. Unfortunately, all these treatments have merely diminished sexual pleasure without prolonging the time of ejaculation.
STRESSFUL SITUATIONS: Dr. Wordell Pomeroy suggests that anxiety producing stress is the root cause of premature ejaculation and ‘possible repetition often becomes another self-fulfilling prophecy’. The therapy recommended is de-sensitization to reduce anxiety.
*365\262\8*

SUMMARY OF INTENSIVE MANAGEMENT OF TYPE 1 DIABETES: SPECIAL ISSUES – ASPIRIN & FLOW SHEET

February 19th, 2011

Aspirin
Aspirin therapy is indicated for some but not all patients with type 1 diabetes. There are limited data about people under age 30, and Reye’s syndrome can be an issue in younger patients. However, type 1 diabetic patients age 30 or older who are at high risk for cardiovascular events are candidates for aspirin therapy. High-risk patients are defined as those with strong family history of coronary heart disease, cigarette use, hypertension, albuminuria, BMI > 27 kg/m2, or altered lipid/lipoprotein profile (mg/dl: cholesterol > 200, LDL-C > 100, triglycerides > 150, and/or HDL-C < 45 (men) or < 55 (women). Many patients have hypertension and/or indicators of diabetic nephropathy.
Flow Sheet
Every type 1 diabetic patient who is under intensive management for glycemia and other micro- and macrovascular risk factors should have a serial flow sheet. Computerized systems are available. Reference to the flow sheet before and during patient visits is an effective way to keep preventive management and the regular evaluations current. The flow sheet is also an excellent tool for discussing with each patient the goals of therapy, their rationale, and the success in achieving them.
*235\354\8*

SUGAR SUBSTITUTES AND DIABETES

February 12th, 2011

Some doctors feel that people with diabetes shouldn’t use sugar substitutes because they simply maintain their “sweet tooth.” If the patients tried eating a more sensible diet, these doctors say, they would soon lose their taste for rich, sweet foods, and that would be a good thing. But some people feel that life just wouldn’t be worth living if they couldn’t have candy, a soft drink, or some other sweet-tasting treat at least occasionally. And some doctors feel that sugar substitutes are good because they permit people with diabetes, especially young ones, to enjoy some of the same treats as their friends, which can help them feel less “different.”
Nutritive sweeteners contain calories, and are usually carbohydrates that end in -ose, such as glucose, fructose, dextrose, and sucrose (sugars), or -ol, such as sorbitol and mannitol (sugar alcohols). They each contain four calories per gram.
Non-nutritive sweeteners provide almost no calories and do not affect blood glucose levels. Saccharin and aspartame (sold under the brand name NutraSweet) are the two major sugar substitutes. Aspartame actually contains the same four calories per gram as do the nutritive sweeteners; however, because it is 180 times sweeter than table sugar, much less has to be used. Saccharin is 300 times sweeter than sucrose and has no calories at all.
Dietetic foods are not necessarily good for people with diabetes. Some contain nutritive sweeteners such as fructose and sorbitol that need to be carefully monitored.
*31\268\2*

REDUCING YOUR RISK OF CORONARY ARTERY DISEASE: EATING FOR BETTER HEALTH – BASIC EATING GUIDELINES – DAIRY PRODUCTS AND MEATS

January 29th, 2011

Dairy products
Best Choices
Skim milk, nonfat yogurt, 1 percent to 2 percent low-fat cheese, and 1 percent to 2 percent low-fat cottage cheese
Go Easy On
2 percent milk, ice milk, low-fat yogurt, creamed cottage cheese (4 percent fat), and part-skim-milk cheeses such as mozzarella, ricotta, and farmer cheese
Limit or Avoid
Whole milk, cheese or yogurt made from whole milk, ice cream, nondairy coffee creamers, and nondairy whipped toppings
Meats
Best Choices
Lean meats (“Select” or “Choice” grade), fish, poultry without the skin, egg whites or egg substitutes, water-packed tuna or salmon, cold cuts or frankfurters that contain no more than 5 grams of fat per 1-ounce serving, dried beans and other legumes
Go Easy On
Peanut butter, nuts, fish canned in oil, oysters, shrimp
Limit or Avoid
Organ meats, egg yolks, fatty and heavily marbled meats (“Prime” grade), spare ribs, regular cold cuts and frankfurters, sausage, bacon, fried meats, canned meats.
*296\252\8*

PREVENTION OF HEART ATTACKS: FORMATION OF ATHEROMA (FATTY DEPOSIT) – THE RISK FACTORS – STRESS

January 22nd, 2011

It was about 25 years ago that I met an acquaintance of mine after a long gap. On a casual inquiry about his posting, I was surprised to learn that he had retired the previous month, meaning thereby that he had completed 58 years of age. As a doctor I am used to assessing the age of my patients and I had, in mind, not placed him beyond the late forties. He looked at least 10 years younger than his age and was in excellent health. I was curious to know the reasons behind his lasting youth. He told me that during his service career of more than 30 years, he was always lucky to get good bosses as well as good subordinates to work with, and never had any problems with either. In fact, his mental make-up was such that he never got himself into conflicts. He kept himself relaxed, worked reasonably hard and remained in good health. He is now in his eighties, still alive and going strong.
I also know of an engineer, a brilliant inventor, who resigned his job to start his own consultancy work. An extremely ambitious man, he was always working against time and encountering obstacles. He suffered the first heart attack at 50, but refused to change his hectic life-style and died of another heart attack at 53. He literally drove himself to death.
These are two contrasting personalities; the former which is relaxed, keeps the heart attacks away and prolongs life; the latter tense, overly anxious and ambitious and working against time, driving a man towards heart problems and finally death.
*75\328\8*

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